The trial, which was conducted at University Hospital, Frankfurt, Germany, showed that women who consumed one tablet containing 4 mg of the extract Rheum rhaponticum, or ERr 731, every day for 12 weeks had a significant reduction in the number and severity of hot flashes, compared with women who took placebo. The reduction of the MRS score was more pronounced in women with a score of > or =18 points at baseline. in a confirmatory rct involving 119 perimenopausal women, compared with perimenopausal women receiving placebo, those receiving err 731 experienced a median 83% decrease in daily hot flashes over the course of 12 weeks. compared to placebo, perimenopausal women who received err 731 (the extract found in estrovera) experienced a decrease in Results: Women in the ERr 731 group in the RCT experienced a further decrease in their symptoms during OS I. Since the beginning of the 1990s, ERr 731 , an extract isolated from the roots of the Siberian rhubarb ( Rheum rhaponticum ), has been used regularly for the treatment of women suffering from oligomenorrhoea or amenorrhea (trade names Phyto-Strol , Mller-Gppingen and femi-loges , Loges). In a clinical trial of 109 women approaching menopause, a rhapontic rhubarb supplement (ERr 731) reduced improved the quality of life and reduced symptoms such as the frequency and severity of hot flashes. ERr 731 has a fair amount of evidence to back its claim as a treatment for menopause symptoms. An older study from 2008 found that. Rhubarb also contains fiber, which might help reduce cholesterol levels and affect stomach conditions. . Long-term use can result in muscular weakness, bone loss, potassium loss, and irregular heart rhythm. It contains an exclusive phytoestrogenic extract of rhapontic (Siberian) rhubarb root known as ERr 731 that has been suggested to be comparable in effectiveness to an ultra low dose of conventional hormone therapies. Because it may be associated with fewer side effects than conventional therapy, . The efficacy of ERr 731(), a commercially available extract isolated from Rheum rhaponticum, in terms of menopausal complaints like hot flushes, depression, anxiety and vaginal dryness has been proven in a two-year clinical study. . Rhubarb can cause some side effects such as stomach and intestinal pain, watery diarrhea, nausea, vomiting, rash, and uterine contractions. 20 ICONIC BENEFITS OF RHUBARB 23 related questions found Does Siberian rhubarb help menopause? Botanical Name: Rheum officinale, R. palmatum and R. tangutucum. Essentially, during menopause levels of estrogen decrease in the body, creating symptoms like hot flashes and night sweats. The efficacy of ERr 731 (), a commercially available extract isolated from Rheum rhaponticum, in terms of menopausal complaints like hot flushes, depression, anxiety and vaginal dryness has been proven in a two-year clinical study. Any product worth its salt will include the standardized rhapontic extract ERr 731, so make sure to check the ingredients list . Standardized rhapontic rhubarb extract (also called "false rhubarb" or "Siberian rhubarb") is easily found in a handful of supplements - usually marketed as "menopause relief" blends - here at home. Long-term use can result in muscular weakness, bone loss, potassium loss, and irregular heart rhythm. Rhubarb can cause some side effects such as stomach and intestinal pain, watery diarrhea, nausea, vomiting, rash, and uterine contractions. Richardson A, et al. 1 25 aglycones, rhapontigenin and desoxyrhapontigenin.6 Neither rhapontic rhubarb nor the special extract ERr 731 contains any of the anthraquinones such as emodin or rhein that are found in other rhubarb species.7 Thus, this extract has no laxative effect. A. What are the side effects of Rhapontic rhubarb? ERr 731 Pharmaceutical & NDI Home ERr 731 is an extensively researched, natural approach for hot flash relief. 2008;14(6):32-8. ERr 731 can help women dealing with: Hot flashes Irritability Mood swings Sleep problems Exhaustion Vaginal dryness Joint and muscle discomfort In addition, it delivers results fairly quickly. German doctors have been using Estrovera to help their menopausal patients for 20 years. Results: After 6 months of treatment with ERr 731 in 252 women, there was a significant decrease of the MRS total score from 14.5 points at baseline to 6.5 points (P<.0001). Efficacy of the special extract ERr 731 from rhapontic rhubarb for menopausal complaints: a 6-month open observational study. The Journal of Steroid Biochemistry and Molecular Biology Volume 128, Issues 1-2, January 2012, Pages 62-68 Long-term effects of the rhapontic rhubarb extract ERr 731 on estrogen-regulated targets in the uterus and on the bone in ovariectomized rats Annekathrin MartinaKeiler1 AnjaPapke1 GeorgKretzschmar Oliver Zierau GnterVollmer Add to Mendeley This plant is a wild relative of the rhubarb plant used in cooking. Its active ingredient is rhapontic rhubarb extract. Researchers found 12 weeks of treatment with a pill containing extract of Rheum rhaponticum, the vegetable more commonly known as rhubarb, significantly reduced the frequency and severity of. Research has shown that rhapontic rhubarb can be an effective remedy for some of the symptoms of menopause, although the mechanism isn't 100% clear. Distributed only by HRS to the World ERr 731 is an extensively researched, natural approach for hot flash relief. The efficacy of ERr 731 (), a commercially available extract isolated from Rheum rhaponticum, in terms of menopausal complaints like hot flushes, depression, anxiety and vaginal dryness has been proven in a two-year clinical study. Note: in botany, the species names "officinale" or "officinalis . Ef cacy of ERr 731 in Perimenopause ALTERNATIVE THERAPIES, jan/feb 2009, VOL. Is Rhapontic rhubarb root extract ERr 731 Safe . There is a report of kidney failure in someone who took a product containing rhubarb. our results demonstrated two key features of err in the uterus of ovariectomized rats: (1) none of the tested doses of the extract if given alone stimulated uterotrophy (table 2) or marker gene expression associated with proliferative events (data not shown); (2) treatment of ovariectomized rats with combinations of low dose estradiol and err Estroven claims that this ingredient activates estrogen receptors and reduces menopausal symptoms. Further a recent preclinical study excluded unwanted side effects on the endometrium by showing a lack of stimulation of proliferation marker genes by ERr 731 . Further a recent preclinical study excluded unwanted side effects on the endometrium by showing a lack of . Importantly, this supplement didn't alter gynecological factors such as uterus health or bleeding [ 21 ]. Long-term use can Women who received placebo during the RCT and started taking ERr 731 in OS I reported a significant decrease in menopausal symptoms. The special extract ERr 731 from the roots of rhapontic rhubarb has been in widespread use in Germany since 1993, and the current regulations have required an evaluation of its risk:benefit ratio . . The key ingredient in Estrovera is a phyto-estrogen from the Siberian rhubarb plant known as ERr 731, which has been shown to: Reduce the number and severity of hot flashes and night sweats about as effectively as low-dose estrogen. All three species are known by the common English name Chinese rhubarb. Altern Ther Health Med. Objective To demonstrate the ef cacy and tolerability of ERr 731 in menopausal women in everyday practice. It contains an exclusive phytoestrogenic extract of rhapontic (Siberian) rhubarb root known as ERr 731 that has been suggested to be comparable in effectiveness to an ultra low dose of conventional hormone therapies. Based on the present research, Siberian rhubarb root is beneficial for perimenopausal and menopausal women experiencing daily symptoms. Estroven's original formula uses only one active ingredient, 4 mg of ERr 731, a standardized extract from the root of Rhapontic Rhubarb. Rhubarb can cause some side effects such as stomach and intestinal pain, watery diarrhea, and uterine contractions. Background The special extract ERr 731 from the roots of rha-pontic rhubarb has been in widespread use in Germany since 1993, and the current regulations have required an evaluation of its risk:bene t ratio in daily use. The efficacy of ERr 731 (), a commercially available extract isolated from Rheum rhaponticum, in terms of menopausal complaints like hot flushes, depression, anxiety and vaginal dryness has. The efficacy of ERr 731(), a commercially available extract isolated from Rheum rhaponticum, in terms of menopausal complaints like hot flushes, depression, anxiety and vaginal dryness has been proven in a two-year clinical study. Garden rhubarb (Rheum rhabarbarum), the familiar red-stalked rhubarb used in cooking in Europe and North America, is a different species and may not have the same medicinal properties. The rhubarb that grows in the back yard is a different species, Rheum rhabarbarum. 15, NO. Scientists tested the rhapontic rhubarb extract in a placebo . Rhubarb contains chemicals that might help heal cold sores and reduce swelling. A preparation containing the Rheum rhaponticum extract ERr731 was registered as medicinal product in 1993 (Phytoestrol N, Chemisch-Pharmazeutische Fabrik Gppingen, Carl Mller, Apotheker, GmbH and Co KG, Gppingen, Germany), which was dedicated to alleviate menopausal complaints as an alternative for the hormonal replacement therapy (HRT). The active ingredient in Estrovera is a standardized extract of rhapontic rhubarb ( Rheum rhaponticum ).

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